734 indexed careers with a surname starting S.
| Player | Years | H | HR | K | Feats |
|---|---|---|---|---|---|
| Kirk Saarloos | 2002–2008 | 3 | 0 | 251 | |
| CC Sabathia | 2001–2019 | 25 | 3 | 3,093 | 1 |
| Bret Saberhagen | 1984–2001 | 23 | 0 | 1,715 | 2 |
| Chris Sabo | 1988–1996 | 898 | 116 | 0 | 2 |
| Ray Sadecki | 1960–1977 | 151 | 5 | 1,614 | |
| Bob Sadowski | 1963–1966 | 13 | 0 | 257 | 1 |
| Olmedo Saenz | 1994–2007 | 438 | 73 | 0 | |
| Vic Saier | 1911–1919 | 775 | 55 | 0 | 5 |
| Johnny Sain | 1942–1955 | 190 | 3 | 913 | 1 |
| Takashi Saito | 2006–2012 | 0 | 0 | 400 | |
| Lenn Sakata | 1977–1987 | 296 | 25 | 0 | |
| Tyler Saladino | 2015–2019 | 221 | 19 | 0 | |
| Fernando Salas | 2010–2019 | 1 | 0 | 474 | |
| Mark Salas | 1984–1991 | 319 | 38 | 0 | |
| Danny Salazar | 2013–2019 | 0 | 0 | 688 | |
| Luis Salazar | 1980–1992 | 1,070 | 94 | 0 | |
| Chris Sale | 2010–2026 | 3 | 0 | 2,756 | 4 |
| Bill Salkeld | 1945–1950 | 232 | 31 | 0 | 1 |
| Slim Sallee | 1908–1921 | 157 | 2 | 839 | 3 |
| Chico Salmon | 1964–1972 | 415 | 31 | 0 | |
| Tim Salmon | 1992–2006 | 1,674 | 299 | 0 | 2 |
| Jarrod Saltalamacchia | 2007–2018 | 662 | 110 | 0 | |
| Manny Salvo | 1939–1943 | 30 | 1 | 247 | |
| Jeff Samardzija | 2008–2020 | 44 | 3 | 1,449 | 1 |
| Joe Sambito | 1976–1987 | 7 | 0 | 489 | |
| Billy Sample | 1978–1986 | 684 | 46 | 0 | 1 |
| Chris Sampson | 2006–2010 | 7 | 0 | 176 | |
| Tommy Sampson | 1940–1949 | 191 | 4 | 0 | 1 |
| Juan Samuel | 1983–1998 | 1,578 | 161 | 0 | 1 |
| Aaron Sanchez | 2014–2022 | 0 | 0 | 541 | |
| Alex Sanchez | 2001–2005 | 452 | 6 | 0 | |
| Anibal Sanchez | 2006–2022 | 29 | 0 | 1,774 | 5 |
| Carlos Sanchez | 2014–2022 | 552 | 32 | 0 | |
| Cristopher Sanchez | 2021–2026 | 0 | 0 | 711 | |
| Freddy Sanchez | 2002–2011 | 1,012 | 48 | 0 | 1 |
| Gaby Sanchez | 2008–2014 | 508 | 61 | 0 | |
| Gary Sanchez | 2015–2026 | 697 | 199 | 0 | 1 |
| Hector Sanchez | 2011–2017 | 186 | 21 | 0 | 1 |
| Jesus Sanchez | 1998–2004 | 25 | 0 | 384 | 1 |
| Jesus Sanchez | 2020–2026 | 514 | 81 | 0 | 1 |
| Jonathan Sanchez | 2006–2013 | 23 | 0 | 796 | 2 |
| Luis Sanchez | 1981–1985 | 0 | 0 | 216 | |
| Rey Sanchez | 1991–2005 | 1,317 | 15 | 0 | 1 |
| Heinie Sand | 1923–1928 | 782 | 18 | 0 | 4 |
| Gus Sandberg | 1923–1926 | 12 | 0 | 0 | 1 |
| Ryne Sandberg | 1981–1997 | 2,386 | 282 | 0 | 1 |
| Deion Sanders | 1989–2001 | 558 | 39 | 0 | |
| Ken Sanders | 1964–1976 | 6 | 0 | 359 | |
| Ray Sanders | 1942–1949 | 597 | 42 | 0 | 2 |
| Reggie Sanders | 1991–2007 | 1,666 | 305 | 0 | 2 |
| Scott Sanders | 1993–1999 | 25 | 0 | 632 | 1 |
| Scott Sanderson | 1978–1996 | 46 | 2 | 1,611 | 2 |
| Mike Sandlock | 1942–1953 | 107 | 2 | 0 | 1 |
| Freddy Sandoval | 2008–2009 | 3 | 0 | 0 | 1 |
| Pablo Sandoval | 2008–2021 | 1,279 | 153 | 0 | 2 |
| Patrick Sandoval | 2019–2026 | 1 | 0 | 577 | |
| Charlie Sands | 1967–1975 | 31 | 6 | 0 | 1 |
| Fred Sanford | 1943–1951 | 39 | 1 | 286 | |
| Jack Sanford | 1956–1967 | 105 | 3 | 1,178 | |
| Manny Sanguillen | 1967–1980 | 1,500 | 65 | 0 | 2 |
| Miguel Sano | 2015–2024 | 602 | 164 | 0 | 2 |
| Carlos Santana | 2010–2026 | 1,882 | 335 | 0 | 1 |
| Danny Santana | 2014–2021 | 443 | 47 | 0 | 1 |
| Domingo Santana | 2014–2020 | 427 | 77 | 0 | |
| Ervin Santana | 2005–2021 | 13 | 0 | 1,978 | 3 |
| Johan Santana | 2000–2012 | 40 | 1 | 1,988 | 2 |
| Julio Santana | 1997–2006 | 2 | 0 | 308 | |
| Rafael Santana | 1983–1990 | 497 | 13 | 0 | 2 |
| Anthony Santander | 2017–2025 | 729 | 161 | 0 | |
| F.P. Santangelo | 1995–2001 | 415 | 21 | 0 | |
| Benito Santiago | 1986–2005 | 1,830 | 217 | 0 | 3 |
| Hector Santiago | 2011–2021 | 3 | 0 | 856 | |
| Jose Santiago | 1963–1970 | 28 | 1 | 404 | |
| Ramon Santiago | 2002–2014 | 591 | 30 | 0 | |
| Ron Santo | 1960–1974 | 2,254 | 342 | 0 | 1 |
| Al Santorini | 1968–1973 | 15 | 1 | 268 | |
| Enyel De Los Santos | 2018–2026 | 0 | 0 | 382 | 1 |
| Sergio Santos | 2010–2015 | 0 | 0 | 227 | 1 |
| Victor Santos | 2001–2007 | 12 | 0 | 425 | |
| Joe Sargent | 1921–1921 | 46 | 2 | 0 | 1 |
| Manny Sarmiento | 1976–1983 | 9 | 0 | 283 | |
| Bill Sarni | 1951–1956 | 311 | 22 | 0 | |
| Andy Sarvis | 1939–1944 | 9 | 0 | 36 | 1 |
| Mackey Sasser | 1987–1995 | 317 | 16 | 0 | |
| Tom Satriano | 1961–1970 | 365 | 21 | 0 | |
| Hank Sauer | 1941–1959 | 1,278 | 288 | 0 | 5 |
| Scott Sauerbeck | 1999–2006 | 0 | 0 | 389 | |
| Joe Saunders | 2005–2014 | 17 | 0 | 792 | 1 |
| Michael Saunders | 2009–2017 | 570 | 81 | 0 | 2 |
| Tony Saunders | 1997–1999 | 5 | 1 | 304 | |
| Bob Savage | 1942–1949 | 9 | 0 | 172 | |
| Ted Savage | 1962–1971 | 321 | 34 | 0 | 1 |
| Carl Sawatski | 1948–1963 | 351 | 58 | 0 | |
| Steve Sax | 1981–1994 | 1,949 | 54 | 0 | |
| Alfred Saylor | 1938–1948 | 24 | 0 | 45 | 1 |
| George Scales | 1921–1946 | 274 | 27 | 0 | |
| Bob Scanlan | 1991–2001 | 2 | 0 | 245 | |
| Doc Scanlan | 1903–1911 | 78 | 0 | 604 | |
| Patricio Scantlebury | 1944–1956 | 67 | 2 | 171 | |
| Ray Scarborough | 1942–1953 | 85 | 1 | 564 | |
| Russ Scarritt | 1929–1932 | 296 | 3 | 0 | 2 |
| Paul Schaal | 1964–1974 | 869 | 57 | 0 | 2 |
| Germany Schaefer | 1901–1918 | 971 | 9 | 0 | 4 |
| Jordan Schafer | 2009–2015 | 295 | 12 | 0 | |
| Ray Schalk | 1912–1929 | 1,345 | 11 | 0 | 14 |
| Roy Schalk | 1932–1945 | 259 | 2 | 0 | 1 |
| Wally Schang | 1913–1931 | 1,506 | 59 | 0 | 6 |
| Nolan Schanuel | 2023–2026 | 397 | 33 | 0 | |
| Charley Schanz | 1944–1950 | 27 | 1 | 244 | |
| George Scharein | 1937–1940 | 317 | 2 | 0 | 3 |
| Dan Schatzeder | 1977–1991 | 58 | 5 | 748 | |
| Rube Schauer | 1913–1917 | 16 | 0 | 168 | |
| Scott Schebler | 2015–2021 | 299 | 61 | 0 | |
| Al Scheer | 1913–1915 | 262 | 5 | 0 | 2 |
| Heinie Scheer | 1922–1929 | 73 | 6 | 0 | 2 |
| Bob Scheffing | 1941–1951 | 357 | 20 | 0 | 1 |
| Carl Scheib | 1943–1954 | 117 | 5 | 291 | |
| Richie Scheinblum | 1965–1974 | 320 | 13 | 0 | |
| Fred Scherman | 1969–1976 | 11 | 0 | 297 | |
| Bill Scherrer | 1982–1988 | 2 | 0 | 207 | |
| Max Scherzer | 2008–2026 | 78 | 1 | 3,525 | 9 |
| Nate Schierholtz | 2007–2014 | 529 | 52 | 0 | |
| Chuck Schilling | 1961–1965 | 470 | 23 | 0 | |
| Curt Schilling | 1988–2007 | 117 | 0 | 3,116 | 2 |
| Calvin Schiraldi | 1984–1991 | 12 | 2 | 471 | |
| Admiral Schlei | 1904–1911 | 455 | 6 | 0 | 1 |
| Dutch Schliebner | 1923–1923 | 141 | 4 | 0 | 1 |
| Ray Schmandt | 1915–1922 | 284 | 3 | 0 | 1 |
| Bob Schmidt | 1958–1965 | 317 | 39 | 0 | 1 |
| Boss Schmidt | 1906–1911 | 358 | 3 | 0 | 2 |
| Butch Schmidt | 1909–1915 | 289 | 4 | 2 | 3 |
| Clarke Schmidt | 2020–2025 | 0 | 0 | 384 | |
| Dave J. Schmidt | 1981–1992 | 0 | 0 | 479 | |
| Henry Schmidt | 1903–1903 | 21 | 1 | 95 | |
| Jason Schmidt | 1995–2009 | 63 | 7 | 1,758 | 2 |
| Mike Schmidt | 1972–1989 | 2,234 | 548 | 0 | 4 |
| Walter Schmidt | 1916–1925 | 619 | 3 | 0 | 2 |
| Willard Schmidt | 1952–1959 | 25 | 0 | 322 | 1 |
| Casey Schmitt | 2023–2026 | 258 | 44 | 0 | 1 |
| Johnny Schmitz | 1941–1956 | 83 | 2 | 749 | 1 |
| Brian Schneider | 2000–2012 | 781 | 67 | 0 | 1 |
| Pete Schneider | 1914–1919 | 96 | 5 | 487 | 1 |
| Red Schoendienst | 1945–1963 | 2,446 | 84 | 0 | |
| Scott Schoeneweis | 1999–2010 | 2 | 0 | 568 | |
| Dick Schofield | 1983–1996 | 989 | 56 | 0 | |
| Dick Schofield | 1953–1971 | 699 | 21 | 0 | |
| Jonathan Schoop | 2013–2023 | 1,095 | 174 | 1 | |
| Gene Schott | 1935–1939 | 42 | 1 | 193 | |
| Pete Schourek | 1991–2001 | 44 | 2 | 813 | 1 |
| Osee Schrecongost | 1897–1908 | 828 | 9 | 0 | |
| Hank Schreiber | 1914–1926 | 18 | 0 | 0 | 1 |
| Pop Schriver | 1897–1901 | 283 | 4 | 0 | |
| Bill Schroeder | 1983–1990 | 303 | 61 | 0 | |
| Ken Schrom | 1980–1987 | 0 | 0 | 372 | |
| Rick Schu | 1984–1996 | 386 | 41 | 0 | |
| Heinie Schuble | 1927–1936 | 235 | 11 | 0 | 1 |
| Ron Schueler | 1972–1979 | 27 | 0 | 563 | |
| Wes Schulmerich | 1930–1934 | 418 | 27 | 0 | |
| Frank Schulte | 1904–1918 | 1,768 | 92 | 0 | 5 |
| Fred Schulte | 1927–1937 | 1,243 | 47 | 0 | 1 |
| Barney Schultz | 1955–1965 | 4 | 0 | 266 | |
| Howie Schultz | 1943–1948 | 381 | 23 | 0 | 4 |
| Joe Schultz | 1912–1925 | 559 | 15 | 0 | 3 |
| Al Schulz | 1912–1916 | 47 | 1 | 449 | 2 |
| Don Schulze | 1983–1989 | 0 | 0 | 144 | |
| Hal Schumacher | 1931–1946 | 181 | 15 | 906 | 2 |
| Skip Schumaker | 2005–2015 | 905 | 28 | 3 | 1 |
| Ferdie Schupp | 1913–1922 | 58 | 1 | 553 | 1 |
| Don Schwall | 1961–1967 | 34 | 0 | 407 | |
| Kyle Schwarber | 2015–2026 | 1,169 | 380 | 0 | 7 |
| Al Schweitzer | 1908–1911 | 207 | 3 | 0 | 2 |
| Mike Scioscia | 1980–1992 | 1,131 | 68 | 0 | |
| Herb Score | 1955–1962 | 36 | 1 | 836 | 1 |
| Ed Scott | 1900–1901 | 29 | 2 | 109 | |
| Everett Scott | 1914–1926 | 1,456 | 20 | 0 | 4 |
| George Scott | 1966–1979 | 1,990 | 271 | 0 | 5 |
| Jack Scott | 1916–1929 | 187 | 5 | 660 | |
| Jim Scott | 1909–1917 | 79 | 1 | 951 | 4 |
| Johnie Scott | 1944–1949 | 202 | 3 | 0 | 2 |
| Luke Scott | 2005–2013 | 725 | 135 | 0 | 1 |
| Mike Scott | 1979–1991 | 81 | 2 | 1,469 | 5 |
| Rodney Scott | 1975–1982 | 504 | 3 | 0 | |
| Tanner Scott | 2017–2026 | 0 | 0 | 613 | |
| Tim Scott | 1991–1997 | 1 | 0 | 253 | |
| Tony Scott | 1973–1984 | 699 | 17 | 0 | 1 |
| Scott Scudder | 1989–1993 | 8 | 1 | 226 | |
| Rod Scurry | 1980–1988 | 9 | 0 | 431 | |
| Marco Scutaro | 2002–2014 | 1,355 | 77 | 0 | |
| Corey Seager | 2015–2026 | 1,316 | 234 | 0 | 2 |
| Kyle Seager | 2011–2021 | 1,395 | 242 | 0 | 2 |
| Rudy Seanez | 1989–2008 | 0 | 0 | 574 | 1 |
| JP Sears | 2022–2026 | 0 | 0 | 491 | |
| Tom Seaton | 1912–1917 | 85 | 4 | 645 | 1 |
| Tom Seats | 1940–1945 | 10 | 0 | 70 | 1 |
| Tom Seaver | 1967–1986 | 202 | 12 | 3,640 | 7 |
| Dick Seay | 1926–1947 | 337 | 12 | 0 | |
| Bob Sebra | 1985–1990 | 14 | 0 | 281 | |
| Jimmy Sebring | 1902–1909 | 368 | 6 | 0 | |
| Bob Seeds | 1930–1940 | 537 | 28 | 0 | |
| Pat Seerey | 1943–1949 | 406 | 86 | 0 | 4 |
| David Segui | 1990–2004 | 1,412 | 139 | 0 | 1 |
| Diego Segui | 1962–1977 | 58 | 4 | 1,298 | |
| Jean Segura | 2012–2023 | 1,545 | 110 | 0 | 1 |
| Socks Seibold | 1915–1933 | 76 | 1 | 303 | |
| Kevin Seitzer | 1986–1997 | 1,557 | 74 | 1 | 1 |
| Kip Selbach | 1897–1906 | 1,375 | 26 | 0 | 1 |
| Aaron Sele | 1993–2007 | 9 | 0 | 1,407 | |
| George Selkirk | 1934–1942 | 810 | 108 | 0 | 3 |
| Epp Sell | 1922–1923 | 4 | 0 | 7 | 1 |
| Jeff Sellers | 1985–1988 | 0 | 0 | 226 | |
| Dick Selma | 1965–1974 | 35 | 0 | 681 | |
| Carey Selph | 1929–1932 | 124 | 0 | 0 | 1 |
| Marcus Semien | 2013–2026 | 1,703 | 267 | 0 | 1 |
| Andy Seminick | 1943–1957 | 954 | 164 | 0 | 1 |
| Ray Semproch | 1958–1961 | 13 | 0 | 156 | |
| Antonio Senzatela | 2017–2026 | 9 | 0 | 585 | |
| Nick Senzel | 2019–2024 | 340 | 40 | 0 | |
| Jae Weong Seo | 2002–2007 | 15 | 0 | 340 | |
| Bill Serena | 1949–1954 | 311 | 48 | 0 | |
| Bonnie Serrell | 1941–1949 | 196 | 15 | 0 | 1 |
| Scott Servais | 1991–2001 | 611 | 63 | 0 | 2 |
| Scott Service | 1988–2004 | 1 | 0 | 413 | |
| Hank Severeid | 1911–1926 | 1,247 | 17 | 0 | 6 |
| Luis Severino | 2015–2026 | 1 | 0 | 1,138 | |
| Pedro Severino | 2015–2022 | 261 | 33 | 0 | 1 |
| Paul Sewald | 2017–2026 | 0 | 0 | 518 | |
| Joe Sewell | 1920–1933 | 2,224 | 49 | 0 | 7 |
| Luke Sewell | 1921–1942 | 1,391 | 20 | 0 | 7 |
| Rip Sewell | 1932–1949 | 152 | 6 | 638 | |
| Richie Sexson | 1997–2008 | 1,286 | 306 | 0 | 4 |
| Socks Seybold | 1899–1908 | 1,086 | 51 | 0 | 1 |
| Cy Seymour | 1897–1913 | 1,719 | 52 | 584 | 1 |
| Tillie Shafer | 1909–1913 | 212 | 5 | 0 | 3 |
| Art Shamsky | 1965–1972 | 426 | 68 | 0 | 1 |
| Wally Shaner | 1923–1929 | 175 | 4 | 0 | 1 |
| Howie Shanks | 1912–1925 | 1,442 | 25 | 0 | 12 |
| Mike Shannon | 1962–1970 | 710 | 68 | 0 | 1 |
| Red Shannon | 1915–1926 | 278 | 0 | 0 | 4 |
| Spike Shannon | 1904–1908 | 677 | 3 | 0 | |
| Bobby Shantz | 1949–1964 | 107 | 1 | 1,075 | |
| Bill Sharp | 1973–1976 | 281 | 9 | 0 | |
| Mike Sharperson | 1987–1995 | 337 | 10 | 0 | |
| Joe Shaute | 1922–1934 | 170 | 1 | 515 | 1 |
| Al Shaw | 1907–1915 | 434 | 14 | 0 | 3 |
| Bob Shaw | 1957–1967 | 69 | 0 | 878 | |
| Bryan Shaw | 2011–2024 | 0 | 0 | 681 | |
| Jeff Shaw | 1990–2001 | 3 | 0 | 545 | |
| Jim Shaw | 1913–1921 | 86 | 4 | 772 | 2 |
| Travis Shaw | 2015–2022 | 563 | 114 | 0 | |
| Bob Shawkey | 1913–1927 | 225 | 3 | 1,365 | 4 |
| Merv Shea | 1927–1944 | 263 | 5 | 0 | 3 |
| Spec Shea | 1947–1955 | 58 | 1 | 360 | 1 |
| Danny Sheaffer | 1987–1997 | 219 | 13 | 0 | 1 |
| Dave Shean | 1906–1919 | 494 | 6 | 0 | 4 |
| Jimmy Sheckard | 1897–1913 | 2,084 | 56 | 0 | 4 |
| Tom Sheehan | 1915–1926 | 39 | 0 | 172 | |
| Tommy Sheehan | 1900–1908 | 238 | 1 | 0 | |
| Earl Sheely | 1921–1931 | 1,339 | 48 | 0 | 7 |
| Andy Sheets | 1996–2002 | 207 | 19 | 0 | |
| Ben Sheets | 2001–2012 | 34 | 0 | 1,325 | 2 |
| Gavin Sheets | 2021–2026 | 498 | 81 | 0 | |
| Larry Sheets | 1984–1993 | 607 | 94 | 0 | |
| Gary Sheffield | 1988–2009 | 2,689 | 509 | 0 | 1 |
| John Shelby | 1981–1991 | 739 | 70 | 0 | |
| Rollie Sheldon | 1961–1966 | 20 | 0 | 371 | |
| Jim Shellenback | 1966–1977 | 14 | 0 | 222 | |
| Chris Shelton | 2004–2009 | 254 | 37 | 0 | |
| Freddie Shepard | 1943–1946 | 20 | 2 | 0 | 1 |
| Jack Shepard | 1953–1956 | 195 | 12 | 0 | 1 |
| Bill Sherdel | 1918–1932 | 214 | 9 | 844 | 1 |
| Roy Sherid | 1929–1931 | 26 | 0 | 150 | |
| Pat Sheridan | 1981–1991 | 611 | 51 | 0 | |
| Monk Sherlock | 1927–1930 | 97 | 0 | 0 | 1 |
| George Sherrill | 2004–2012 | 0 | 0 | 320 | |
| Larry Sherry | 1958–1968 | 25 | 3 | 602 | |
| Norm Sherry | 1959–1963 | 107 | 18 | 0 | 1 |
| James Shields | 2006–2018 | 24 | 0 | 2,234 | 1 |
| Scot Shields | 2001–2010 | 0 | 0 | 631 | |
| Billy Shindle | 1897–1898 | 260 | 5 | 0 | |
| Craig Shipley | 1986–1998 | 364 | 20 | 0 | |
| Art Shires | 1928–1932 | 287 | 11 | 0 | 1 |
| Bob Shirley | 1977–1987 | 29 | 0 | 790 | |
| Mule Shirley | 1924–1925 | 21 | 0 | 0 | 1 |
| Tex Shirley | 1941–1946 | 34 | 0 | 168 | |
| Urban Shocker | 1916–1928 | 167 | 1 | 988 | |
| Matt Shoemaker | 2013–2021 | 0 | 0 | 580 | |
| Milt Shoffner | 1929–1940 | 31 | 2 | 180 | |
| Kelly Shoppach | 2005–2013 | 361 | 70 | 0 | 2 |
| Ernie Shore | 1912–1920 | 38 | 0 | 313 | 1 |
| Bill Shores | 1928–1936 | 21 | 0 | 131 | |
| Chris Short | 1959–1973 | 88 | 0 | 1,629 | 1 |
| Chick Shorten | 1915–1924 | 370 | 3 | 0 | 2 |
| Burt Shotton | 1909–1923 | 1,339 | 9 | 0 | 2 |
| Clyde Shoun | 1935–1949 | 73 | 0 | 486 | 2 |
| Brian Shouse | 1993–2009 | 0 | 0 | 233 | |
| Eric Show | 1981–1991 | 81 | 4 | 971 | |
| Chasen Shreve | 2014–2024 | 0 | 0 | 387 | |
| George Shuba | 1948–1955 | 211 | 24 | 0 | 2 |
| J.B. Shuck | 2011–2019 | 285 | 8 | 0 | |
| Paul Shuey | 1994–2007 | 1 | 0 | 556 | 1 |
| Terry Shumpert | 1990–2003 | 497 | 49 | 0 | 1 |
| Ed Sicking | 1916–1927 | 135 | 0 | 0 | 2 |
| Norm Siebern | 1956–1968 | 1,217 | 132 | 0 | |
| Dick Siebert | 1932–1945 | 1,104 | 32 | 0 | 1 |
| Sonny Siebert | 1964–1975 | 114 | 12 | 1,512 | 4 |
| Ruben Sierra | 1986–2006 | 2,152 | 306 | 0 | 2 |
| Ed Siever | 1901–1908 | 82 | 0 | 479 | |
| Roy Sievers | 1949–1965 | 1,703 | 318 | 0 | 1 |
| Frank Sigafoos | 1926–1931 | 27 | 0 | 0 | 1 |
| Carlos Silva | 2002–2010 | 5 | 0 | 554 | |
| Jose Silva | 1996–2002 | 10 | 0 | 298 | |
| Al Sima | 1950–1954 | 9 | 1 | 111 | |
| Bill Simas | 1995–2000 | 0 | 0 | 265 | |
| Al Simmons | 1924–1944 | 2,929 | 307 | 0 | 3 |
| Andrelton Simmons | 2012–2022 | 1,169 | 70 | 0 | |
| Curt Simmons | 1947–1967 | 194 | 1 | 1,700 | 1 |
| Hack Simmons | 1910–1915 | 234 | 2 | 0 | 3 |
| Ted Simmons | 1968–1988 | 2,472 | 248 | 0 | |
| Willie Simms | 1936–1944 | 178 | 4 | 0 | 1 |
| Alfredo Simon | 2008–2016 | 9 | 0 | 529 | 1 |
| Mike Simon | 1909–1915 | 244 | 1 | 0 | 1 |
| Randall Simon | 1997–2006 | 455 | 49 | 0 | |
| Jason Simontacchi | 2002–2007 | 19 | 0 | 191 | |
| Dick Simpson | 1962–1969 | 107 | 15 | 0 | 1 |
| Harry Simpson | 1946–1959 | 861 | 79 | 0 | 1 |
| Joe Simpson | 1975–1983 | 338 | 9 | 1 | |
| Wayne Simpson | 1970–1977 | 12 | 0 | 353 | 1 |
| Duke Sims | 1964–1974 | 580 | 100 | 0 | 2 |
| Lucas Sims | 2017–2026 | 2 | 0 | 376 | |
| Bill Singer | 1964–1977 | 45 | 0 | 1,515 | 2 |
| Brady Singer | 2020–2026 | 0 | 0 | 920 | 1 |
| Chris Singleton | 1999–2005 | 609 | 45 | 0 | 1 |
| Elmer Singleton | 1945–1959 | 9 | 0 | 165 | |
| Ken Singleton | 1970–1984 | 2,029 | 246 | 0 | 1 |
| Fred Sington | 1934–1939 | 139 | 7 | 0 | 1 |
| Tony Sipp | 2009–2019 | 0 | 0 | 531 | |
| Jose Siri | 2021–2026 | 269 | 61 | 0 | |
| Mike Sirotka | 1995–2000 | 2 | 0 | 435 | |
| Doug Sisk | 1982–1991 | 4 | 0 | 195 | |
| Tommie Sisk | 1962–1970 | 22 | 0 | 441 | |
| Dave Sisler | 1956–1962 | 25 | 0 | 355 | 1 |
| Dick Sisler | 1946–1953 | 720 | 55 | 0 | |
| George Sisler | 1915–1930 | 2,806 | 102 | 63 | 7 |
| Sibby Sisti | 1939–1954 | 732 | 27 | 0 | |
| Grady Sizemore | 2004–2015 | 1,098 | 150 | 0 | |
| Ted Sizemore | 1969–1980 | 1,311 | 23 | 0 | 1 |
| Tyler Skaggs | 2012–2019 | 2 | 0 | 476 | |
| Paul Skenes | 2024–2026 | 0 | 0 | 561 | |
| Bob Skinner | 1954–1966 | 1,198 | 103 | 0 | |
| Joel Skinner | 1983–1991 | 329 | 17 | 0 | |
| Bill Skowron | 1954–1967 | 1,566 | 211 | 0 | 1 |
| Tarik Skubal | 2020–2026 | 0 | 0 | 1,042 | |
| Gordon Slade | 1930–1935 | 353 | 8 | 0 | |
| Jimmy Slagle | 1899–1908 | 1,343 | 2 | 0 | 2 |
| Austin Slater | 2017–2026 | 420 | 45 | 0 | 1 |
| Jim Slaton | 1971–1986 | 6 | 0 | 1,191 | |
| Don Slaught | 1982–1997 | 1,151 | 77 | 0 | 3 |
| Enos Slaughter | 1938–1959 | 2,380 | 169 | 0 | 1 |
| Lou Sleater | 1950–1958 | 21 | 4 | 151 | |
| Heathcliff Slocumb | 1991–2000 | 1 | 0 | 513 | |
| Kevin Slowey | 2007–2014 | 3 | 0 | 495 | |
| Joe Slusarski | 1991–2001 | 1 | 0 | 173 | |
| Andy Van Slyke | 1983–1995 | 1,562 | 164 | 0 | |
| Aaron Small | 1994–2006 | 0 | 0 | 170 | |
| Roy Smalley | 1975–1987 | 1,454 | 163 | 0 | 2 |
| Roy Smalley | 1948–1958 | 601 | 61 | 0 | 3 |
| John Smiley | 1986–1997 | 73 | 2 | 1,284 | 2 |
| Al Smith | 1946–1964 | 1,509 | 171 | 0 | |
| Al Smith | 1934–1945 | 102 | 2 | 587 | 2 |
| Aleck Smith | 1897–1906 | 252 | 1 | 0 | |
| Billy Smith | 1975–1981 | 234 | 17 | 0 | |
| Bob Smith | 1998–2002 | 192 | 21 | 0 | 2 |
| Bob Smith | 1923–1937 | 412 | 5 | 618 | 2 |
| Bobby Smith | 1957–1965 | 234 | 13 | 0 | 2 |
| Bryn Smith | 1981–1993 | 76 | 3 | 1,028 | 1 |
| Bud Smith | 2001–2002 | 7 | 0 | 81 | 2 |
| Caleb Smith | 2017–2022 | 15 | 0 | 478 | |
| Charley Smith | 1960–1969 | 594 | 69 | 0 | |
| Charlie Smith | 1929–1930 | 8 | 7 | 0 | 1 |
| Charlie Smith | 1902–1914 | 67 | 1 | 577 | |
| Dave Smith | 1980–1992 | 3 | 0 | 548 | |
| Dominic Smith | 2017–2026 | 629 | 77 | 0 | |
| Dwight Smith | 1989–1996 | 497 | 46 | 0 | |
| Earl Smith | 1916–1922 | 429 | 9 | 0 | |
| Earl Smith | 1919–1930 | 687 | 46 | 0 | |
| Eddie Smith | 1936–1947 | 100 | 1 | 694 | |
| Elmer Smith | 1914–1931 | 880 | 70 | 0 | 4 |
| Eugene Smith | 1940–1949 | 35 | 6 | 187 | |
| Ford Smith | 1939–1948 | 43 | 2 | 105 | |
| Frank Smith | 1950–1956 | 10 | 0 | 278 | |
| Frank Smith | 1904–1915 | 156 | 2 | 1,066 | 6 |
| Fred Smith | 1913–1917 | 320 | 8 | 0 | 2 |
| George Smith | 1926–1930 | 23 | 2 | 138 | 2 |
| George Smith | 1916–1923 | 34 | 0 | 267 | 1 |
| Hal Smith | 1955–1964 | 715 | 58 | 0 | |
| Hal Smith | 1956–1965 | 437 | 23 | 0 | |
| Harry Smith | 1901–1910 | 214 | 2 | 0 | 1 |
| Heinie Smith | 1897–1903 | 268 | 3 | 5 | |
| Hilton Smith | 1935–1948 | 148 | 5 | 458 | 2 |
| Jack Smith | 1915–1931 | 1,301 | 40 | 0 | |
| Jimmy Smith | 1914–1922 | 247 | 12 | 0 | 2 |
| Joe Smith | 2007–2022 | 0 | 0 | 666 | |
| Joe Smith | 1913–1913 | 5 | 0 | 0 | 1 |
| Josh Smith | 2022–2026 | 373 | 34 | 0 | |
| Lee Smith | 1980–1997 | 3 | 1 | 1,251 | 1 |
| Lonnie Smith | 1978–1994 | 1,488 | 98 | 0 | 1 |
| Mallex Smith | 2016–2020 | 378 | 13 | 0 | |
| Mark Smith | 1994–2003 | 233 | 32 | 0 | 1 |
| Mayo Smith | 1945–1945 | 43 | 0 | 0 | 1 |
| Mike Smith | 1897–1901 | 534 | 11 | 0 | |
| Ozzie Smith | 1978–1996 | 2,460 | 28 | 0 | |
| Pavin Smith | 2020–2026 | 344 | 46 | 0 | 1 |
| Pete Smith | 1987–1998 | 33 | 0 | 640 | |
| Red Smith | 1911–1919 | 1,087 | 27 | 0 | 8 |
| Reggie Smith | 1966–1982 | 2,020 | 314 | 0 | 1 |
| Roy Smith | 1984–1991 | 0 | 0 | 320 | |
| Seth Smith | 2007–2017 | 933 | 126 | 0 | |
| Sherry Smith | 1911–1928 | 165 | 6 | 429 | 1 |
| Theolic Smith | 1935–1951 | 49 | 1 | 139 | |
| Will Smith | 2012–2024 | 1 | 0 | 748 | 1 |
| Will Smith | 2019–2026 | 704 | 134 | 0 | |
| Willie Smith | 1958–1971 | 410 | 46 | 40 | 1 |
| Zane Smith | 1984–1996 | 87 | 0 | 1,011 | 2 |
| Mike Smithson | 1982–1989 | 0 | 0 | 731 | |
| Justin Smoak | 2010–2020 | 951 | 196 | 0 | 2 |
| John Smoltz | 1988–2009 | 151 | 5 | 3,084 | 2 |
| Homer Smoot | 1902–1906 | 763 | 15 | 0 | |
| Frank Smykal | 1916–1916 | 3 | 0 | 0 | 1 |
| Drew Smyly | 2012–2024 | 3 | 0 | 1,119 | |
| Blake Snell | 2016–2026 | 4 | 0 | 1,476 | 3 |
| Ian Snell | 2004–2010 | 18 | 0 | 639 | |
| Duke Snider | 1947–1964 | 2,107 | 407 | 0 | 2 |
| Travis Snider | 2008–2015 | 435 | 54 | 1 | |
| Fred Snodgrass | 1908–1916 | 852 | 11 | 0 | 8 |
| Chris Snopek | 1995–1998 | 142 | 13 | 0 | 1 |
| Felton Snow | 1931–1947 | 475 | 15 | 4 | 2 |
| J.T. Snow | 1992–2008 | 1,508 | 189 | 0 | 2 |
| Chris Snyder | 2004–2013 | 467 | 77 | 0 | |
| Cory Snyder | 1986–1994 | 902 | 149 | 0 | 2 |
| Frank Snyder | 1912–1927 | 1,122 | 47 | 0 | 7 |
| John Snyder | 1998–2000 | 3 | 0 | 188 | |
| Russ Snyder | 1959–1970 | 984 | 42 | 0 | |
| Eric Soderholm | 1971–1980 | 764 | 102 | 0 | |
| Tyler Soderstrom | 2023–2026 | 316 | 56 | 0 | 1 |
| Rick Sofield | 1979–1981 | 149 | 9 | 0 | 1 |
| Eric Sogard | 2010–2021 | 551 | 26 | 1 | |
| Luis Sojo | 1990–2003 | 669 | 36 | 0 | |
| Tony Solaita | 1968–1979 | 336 | 50 | 0 | 2 |
| Nick Solak | 2019–2026 | 220 | 21 | 0 | 1 |
| Donovan Solano | 2012–2025 | 805 | 43 | 0 | |
| Yangervis Solarte | 2014–2019 | 620 | 75 | 0 | 1 |
| Jorge Soler | 2014–2026 | 979 | 215 | 0 | 2 |
| Eddie Solomon | 1973–1982 | 39 | 0 | 337 | |
| Moose Solters | 1934–1943 | 990 | 83 | 0 | 2 |
| Jock Somerlott | 1910–1911 | 21 | 0 | 0 | 2 |
| Andy Sonnanstine | 2007–2011 | 7 | 0 | 343 | |
| Lary Sorensen | 1977–1988 | 3 | 0 | 569 | |
| Joakim Soria | 2007–2021 | 0 | 0 | 830 | |
| Alfonso Soriano | 1999–2014 | 2,095 | 412 | 0 | 4 |
| Jose Soriano | 2023–2026 | 0 | 0 | 454 | |
| Rafael Soriano | 2002–2015 | 0 | 0 | 641 | 1 |
| Mike Soroka | 2018–2025 | 5 | 0 | 379 | |
| Vic Sorrell | 1928–1937 | 77 | 0 | 616 | 1 |
| Paul Sorrento | 1989–1999 | 876 | 166 | 0 | |
| Edmundo Sosa | 2018–2026 | 367 | 42 | 0 | 1 |
| Elias Sosa | 1972–1983 | 12 | 0 | 538 | |
| Jorge Sosa | 2002–2010 | 12 | 3 | 491 | |
| Lenyn Sosa | 2022–2026 | 285 | 38 | 0 | |
| Sammy Sosa | 1989–2007 | 2,406 | 609 | 0 | 12 |
| Denny Sothern | 1926–1931 | 379 | 19 | 0 | |
| Allen Sothoron | 1914–1926 | 114 | 0 | 575 | 1 |
| Geovany Soto | 2005–2017 | 619 | 108 | 0 | 1 |
| Gregory Soto | 2019–2026 | 2 | 0 | 478 | |
| Juan Soto | 2018–2026 | 1,170 | 265 | 0 | 3 |
| Mario Soto | 1977–1988 | 70 | 1 | 1,449 | 1 |
| Bud Souchock | 1946–1955 | 313 | 50 | 0 | 1 |
| Herb Souell | 1940–1950 | 415 | 10 | 0 | 1 |
| Billy Southworth | 1913–1929 | 1,296 | 52 | 0 | 7 |
| Steven Souza | 2014–2022 | 383 | 72 | 0 | |
| Jeremy Sowers | 2006–2009 | 1 | 0 | 174 | |
| Bob Spade | 1907–1910 | 32 | 0 | 123 | |
| Warren Spahn | 1942–1965 | 362 | 35 | 2,582 | 7 |
| Denard Span | 2008–2018 | 1,497 | 71 | 0 | 1 |
| Cory Spangenberg | 2014–2022 | 320 | 29 | 0 | |
| Al Spangler | 1959–1971 | 594 | 21 | 0 | |
| Steve Sparks | 1995–2004 | 5 | 0 | 658 | |
| Tully Sparks | 1897–1910 | 92 | 0 | 796 | 2 |
| Joe Sparma | 1964–1970 | 32 | 0 | 586 | |
| Tris Speaker | 1907–1928 | 3,516 | 117 | 0 | 6 |
| Henry Spearman | 1935–1945 | 373 | 30 | 0 | |
| By Speece | 1924–1930 | 9 | 0 | 53 | 1 |
| Chris Speier | 1971–1989 | 1,759 | 112 | 0 | 4 |
| Justin Speier | 1998–2009 | 3 | 0 | 588 | |
| Stan Spence | 1940–1949 | 1,090 | 95 | 0 | 3 |
| Daryl Spencer | 1952–1963 | 901 | 105 | 0 | 3 |
| Glenn Spencer | 1928–1933 | 19 | 0 | 161 | |
| Jim Spencer | 1968–1982 | 1,227 | 146 | 0 | |
| Roy Spencer | 1925–1938 | 445 | 3 | 0 | 4 |
| Shane Spencer | 1998–2004 | 438 | 59 | 0 | 1 |
| Tubby Spencer | 1905–1918 | 299 | 3 | 0 | 1 |
| Vern Spencer | 1920–1920 | 28 | 0 | 0 | 1 |
| Bill Spiers | 1989–2001 | 922 | 37 | 0 | |
| Ed Spiezio | 1964–1972 | 367 | 39 | 0 | 1 |
| Scott Spiezio | 1996–2007 | 996 | 119 | 0 | 1 |
| Charlie Spikes | 1972–1980 | 502 | 65 | 0 | 2 |
| Ryan Spilborghs | 2005–2011 | 424 | 42 | 0 | |
| Dan Spillner | 1974–1985 | 10 | 0 | 878 | 2 |
| Junior Spivey | 2001–2005 | 419 | 48 | 0 | |
| Paul Splittorff | 1970–1984 | 22 | 0 | 1,057 | 2 |
| Al Spohrer | 1928–1935 | 574 | 6 | 0 | 1 |
| Jerry Spradlin | 1993–2000 | 1 | 0 | 292 | 1 |
| Ed Sprague | 1991–2001 | 1,010 | 152 | 0 | 1 |
| Ed Sprague | 1968–1976 | 1 | 0 | 188 | |
| Dennis Springer | 1995–2002 | 7 | 0 | 296 | |
| George Springer | 2014–2026 | 1,577 | 307 | 0 | 3 |
| Russ Springer | 1992–2010 | 2 | 0 | 775 | |
| Jeffrey Springs | 2018–2026 | 0 | 0 | 589 | |
| Freddy Spurgeon | 1924–1927 | 335 | 1 | 0 | 2 |
| Mike Squires | 1975–1985 | 411 | 6 | 0 | |
| Eddie Stack | 1910–1914 | 17 | 0 | 200 | |
| Bill Stafford | 1960–1967 | 38 | 0 | 450 | 1 |
| General Stafford | 1897–1899 | 295 | 13 | 0 | |
| Chick Stahl | 1897–1906 | 1,547 | 37 | 0 | 1 |
| Jake Stahl | 1903–1913 | 894 | 31 | 0 | 5 |
| Larry Stahl | 1964–1973 | 400 | 36 | 0 | |
| Scott Stahoviak | 1993–1998 | 261 | 27 | 0 | |
| Tuck Stainback | 1933–1946 | 586 | 17 | 0 | |
| Matt Stairs | 1992–2011 | 1,366 | 265 | 0 | |
| Gerry Staley | 1947–1961 | 66 | 1 | 726 | 1 |
| Tracy Stallard | 1960–1966 | 27 | 0 | 477 | |
| Virgil Stallcup | 1947–1953 | 498 | 22 | 0 | 1 |
| Jacob Stallings | 2016–2025 | 395 | 33 | 2 | |
| Craig Stammen | 2009–2022 | 22 | 0 | 743 | 1 |
| Oscar Stanage | 1906–1925 | 819 | 8 | 0 | 13 |
| Ryne Stanek | 2017–2026 | 0 | 0 | 586 | |
| Lee Stange | 1961–1970 | 24 | 0 | 719 | |
| Don Stanhouse | 1972–1982 | 25 | 1 | 408 | |
| Eddie Stanky | 1943–1953 | 1,151 | 29 | 0 | 4 |
| Bob Stanley | 1977–1989 | 0 | 0 | 693 | |
| Fred Stanley | 1969–1982 | 356 | 10 | 0 | 3 |
| Jim Stanley | 1914–1914 | 19 | 0 | 0 | 1 |
| Mickey Stanley | 1964–1978 | 1,243 | 117 | 0 | |
| Mike Stanley | 1986–2000 | 1,138 | 187 | 0 | 2 |
| Neck Stanley | 1931–1948 | 33 | 0 | 207 | |
| Giancarlo Stanton | 2010–2026 | 1,642 | 456 | 0 | 2 |
| Leroy Stanton | 1970–1978 | 628 | 77 | 0 | 2 |
| Mike Stanton | 1975–1985 | 1 | 0 | 304 | |
| Mike Stanton | 1989–2007 | 8 | 0 | 895 | 1 |
| Dave Stapleton | 1980–1986 | 550 | 41 | 0 | |
| Willie Stargell | 1962–1982 | 2,232 | 475 | 0 | 7 |
| Dolly Stark | 1909–1912 | 89 | 0 | 0 | 2 |
| Dick Starr | 1947–1951 | 15 | 0 | 120 | |
| Ray Starr | 1932–1945 | 27 | 0 | 188 | |
| Max Stassi | 2013–2022 | 241 | 41 | 0 | 1 |
| Jigger Statz | 1919–1935 | 737 | 17 | 0 | 4 |
| Rusty Staub | 1963–1985 | 2,716 | 292 | 0 | 1 |
| Tim Stauffer | 2005–2015 | 21 | 0 | 449 | |
| Turkey Stearnes | 1924–1940 | 440 | 57 | 0 | |
| John Stearns | 1974–1984 | 696 | 46 | 0 | |
| Bill Steele | 1910–1914 | 48 | 0 | 232 | 1 |
| Bob Steele | 1916–1919 | 40 | 0 | 220 | |
| Ed Steele | 1942–1951 | 220 | 20 | 0 | 1 |
| Elmer Steele | 1907–1911 | 18 | 0 | 149 | 1 |
| Justin Steele | 2021–2025 | 2 | 0 | 517 | |
| Bill Steen | 1912–1915 | 42 | 0 | 264 | |
| Spencer Steer | 2022–2026 | 509 | 82 | 0 | 1 |
| Dave Stegman | 1978–1984 | 66 | 8 | 0 | 1 |
| Bill Stein | 1972–1985 | 751 | 44 | 0 | 1 |
| Blake Stein | 1998–2002 | 0 | 0 | 369 | 1 |
| Terry Steinbach | 1986–1999 | 1,453 | 162 | 0 | |
| Hank Steinbacher | 1937–1939 | 170 | 6 | 0 | 1 |
| Ray Steineder | 1923–1924 | 10 | 0 | 34 | 1 |
| Harry Steinfeldt | 1898–1911 | 1,582 | 27 | 0 | 4 |
| Tommy La Stella | 2014–2023 | 462 | 40 | 0 | |
| Casey Stengel | 1912–1926 | 1,223 | 60 | 0 | 9 |
| Dave Stenhouse | 1962–1964 | 11 | 0 | 215 | |
| Rennie Stennett | 1971–1981 | 1,239 | 41 | 0 | 2 |
| Jake Stenzel | 1897–1899 | 382 | 6 | 0 | 1 |
| Bryan Stephens | 1947–1948 | 7 | 0 | 69 | 1 |
| Gene Stephens | 1952–1964 | 460 | 37 | 0 | 1 |
| Jim Stephens | 1907–1912 | 276 | 3 | 0 | 1 |
| Vern Stephens | 1941–1955 | 1,858 | 247 | 0 | 3 |
| Garrett Stephenson | 1996–2003 | 18 | 0 | 408 | |
| John Stephenson | 1964–1973 | 214 | 12 | 0 | |
| Riggs Stephenson | 1921–1934 | 1,515 | 63 | 0 | 3 |
| Robert Stephenson | 2016–2025 | 1 | 0 | 416 | |
| Tyler Stephenson | 2020–2026 | 542 | 76 | 0 | 3 |
| Dutch Sterrett | 1912–1913 | 68 | 1 | 0 | 3 |
| Chuck Stevens | 1941–1948 | 184 | 4 | 0 | 1 |
| Ed Stevens | 1945–1950 | 306 | 28 | 0 | 1 |
| Lee Stevens | 1990–2002 | 847 | 144 | 0 | 1 |
| Bud Stewart | 1941–1954 | 547 | 32 | 0 | |
| Chris Stewart | 2006–2018 | 272 | 9 | 0 | 1 |
| DJ Stewart | 2018–2024 | 179 | 42 | 0 | 1 |
| Dave Stewart | 1978–1995 | 10 | 0 | 1,741 | 3 |
| Ian Stewart | 2007–2014 | 341 | 61 | 0 | |
| Jimmy Stewart | 1963–1973 | 336 | 8 | 0 | |
| Lefty Stewart | 1921–1935 | 115 | 0 | 505 | |
| Sammy Stewart | 1978–1987 | 0 | 0 | 586 | |
| Shannon Stewart | 1995–2008 | 1,653 | 115 | 0 | |
| Stuffy Stewart | 1916–1929 | 65 | 1 | 0 | 1 |
| Zach Stewart | 2011–2012 | 0 | 0 | 64 | 1 |
| Dave Stieb | 1979–1998 | 0 | 0 | 1,669 | 7 |
| Dick Stigman | 1960–1966 | 32 | 0 | 755 | |
| Kurt Stillwell | 1986–1996 | 779 | 34 | 0 | 1 |
| Kelly Stinnett | 1994–2007 | 476 | 65 | 0 | |
| Bob Stinson | 1969–1980 | 408 | 33 | 0 | 3 |
| Snuffy Stirnweiss | 1943–1952 | 989 | 29 | 0 | |
| Chuck Stobbs | 1947–1961 | 102 | 0 | 900 | |
| Milt Stock | 1913–1926 | 1,806 | 22 | 0 | 5 |
| Wes Stock | 1959–1967 | 3 | 0 | 365 | |
| Kevin Stocker | 1993–2000 | 703 | 23 | 0 | |
| Bob Stoddard | 1981–1987 | 0 | 0 | 223 | |
| Tim Stoddard | 1975–1989 | 2 | 1 | 582 | |
| Dean Stone | 1953–1963 | 15 | 1 | 381 | |
| Ed Stone | 1933–1946 | 467 | 39 | 0 | |
| George Stone | 1903–1910 | 983 | 23 | 0 | 1 |
| George Stone | 1967–1975 | 72 | 1 | 590 | |
| Jeff Stone | 1983–1990 | 261 | 11 | 0 | |
| John Stone | 1928–1938 | 1,390 | 77 | 0 | 1 |
| Steve Stone | 1971–1981 | 22 | 0 | 1,065 | |
| Bill Stoneman | 1967–1974 | 29 | 0 | 934 | 5 |
| Lil Stoner | 1922–1931 | 58 | 2 | 297 | 1 |
| Drew Storen | 2010–2017 | 1 | 0 | 417 | 1 |
| Trevor Story | 2016–2026 | 1,103 | 206 | 0 | 4 |
| Bryson Stott | 2022–2026 | 633 | 58 | 0 | 1 |
| Mel Stottlemyre | 1964–1974 | 120 | 7 | 1,259 | 3 |
| Todd Stottlemyre | 1988–2002 | 50 | 1 | 1,587 | 2 |
| Allyn Stout | 1930–1943 | 18 | 1 | 185 | |
| George Stovall | 1904–1915 | 1,377 | 15 | 0 | 6 |
| Kyle Stowers | 2022–2026 | 269 | 47 | 0 | 1 |
| Matt Strahm | 2016–2026 | 6 | 0 | 612 | |
| Dan Straily | 2012–2019 | 10 | 0 | 681 | |
| Sammy Strang | 1900–1908 | 777 | 16 | 0 | |
| Alan Strange | 1934–1942 | 211 | 1 | 0 | |
| Doug Strange | 1989–1998 | 434 | 31 | 0 | |
| Stephen Strasburg | 2010–2022 | 67 | 4 | 1,723 | 1 |
| Chris Stratton | 2016–2025 | 8 | 0 | 570 | |
| Monty Stratton | 1934–1938 | 43 | 4 | 196 | |
| Myles Straw | 2018–2026 | 556 | 13 | 0 | |
| Darryl Strawberry | 1983–1999 | 1,401 | 335 | 0 | 4 |
| Gabby Street | 1904–1931 | 310 | 2 | 0 | 6 |
| Huston Street | 2005–2017 | 0 | 0 | 665 | |
| George Strickland | 1950–1960 | 633 | 36 | 0 | 2 |
| Hunter Strickland | 2014–2025 | 0 | 0 | 422 | |
| Elmer Stricklett | 1904–1907 | 45 | 0 | 235 | |
| Spencer Strider | 2021–2026 | 0 | 0 | 672 | |
| Nick Strincevich | 1940–1948 | 43 | 0 | 277 | 1 |
| Lou Stringer | 1941–1950 | 290 | 19 | 0 | 2 |
| Ross Stripling | 2016–2024 | 8 | 0 | 741 | |
| Joe Stripp | 1928–1938 | 1,238 | 24 | 0 | 4 |
| John Strohmayer | 1970–1974 | 10 | 0 | 200 | |
| Brent Strom | 1972–1977 | 8 | 0 | 278 | |
| Marcus Stroman | 2014–2025 | 9 | 1 | 1,230 | 1 |
| Joe Strong | 1924–1937 | 35 | 3 | 73 | 1 |
| Pedro Strop | 2009–2021 | 0 | 0 | 554 | |
| Ed Stroud | 1966–1971 | 320 | 14 | 0 | |
| Sailor Stroud | 1910–1916 | 11 | 0 | 147 | |
| Amos Strunk | 1908–1924 | 1,419 | 15 | 0 | 6 |
| Dick Stuart | 1958–1969 | 1,055 | 228 | 0 | 2 |
| Johnny Stuart | 1922–1925 | 29 | 0 | 124 | |
| Marlin Stuart | 1949–1954 | 23 | 1 | 185 | |
| Drew Stubbs | 2009–2017 | 687 | 92 | 0 | 1 |
| Franklin Stubbs | 1984–1995 | 602 | 104 | 0 | 3 |
| Eric Stults | 2006–2015 | 33 | 1 | 433 | |
| Bill Stumpf | 1912–1913 | 37 | 0 | 0 | 1 |
| John Stuper | 1982–1985 | 15 | 0 | 191 | |
| Tom Sturdivant | 1955–1964 | 60 | 0 | 705 | 1 |
| Bobby Sturgeon | 1940–1948 | 313 | 1 | 0 | |
| Tanyon Sturtze | 1995–2008 | 1 | 0 | 480 | |
| Chris Stynes | 1995–2004 | 640 | 51 | 0 | 1 |
| Eugenio Suarez | 2014–2026 | 1,510 | 345 | 0 | 4 |
| Jose Suarez | 2019–2026 | 0 | 0 | 422 | |
| Ranger Suarez | 2018–2026 | 5 | 0 | 822 | |
| Bill Sudakis | 1968–1975 | 362 | 59 | 0 | |
| Pete Suder | 1941–1955 | 1,268 | 49 | 0 | 1 |
| Willie Sudhoff | 1897–1906 | 149 | 1 | 523 | |
| Joe Sugden | 1897–1912 | 489 | 0 | 0 | |
| George Suggs | 1908–1915 | 112 | 1 | 591 | 2 |
| Gus Suhr | 1929–1945 | 1,446 | 84 | 0 | 1 |
| Clyde Sukeforth | 1926–1945 | 326 | 2 | 0 | |
| Billy Sullivan | 1899–1916 | 775 | 21 | 0 | 2 |
| Billy Sullivan | 1931–1947 | 820 | 29 | 0 | 3 |
| Cory Sullivan | 2005–2010 | 305 | 10 | 0 | |
| Denny Sullivan | 1905–1909 | 220 | 1 | 0 | 1 |
| Frank Sullivan | 1953–1963 | 76 | 0 | 960 | |
| Joe Sullivan | 1935–1941 | 43 | 0 | 216 | |
| John Sullivan | 1942–1949 | 420 | 1 | 0 | 2 |
| Scott Sullivan | 1995–2004 | 4 | 0 | 622 | |
| Homer Summa | 1920–1930 | 904 | 18 | 0 | 3 |
| Champ Summers | 1974–1984 | 350 | 54 | 0 | |
| Ed Summers | 1908–1912 | 57 | 2 | 369 | 1 |
| Jim Sundberg | 1974–1989 | 1,493 | 95 | 0 | 1 |
| Steve Sundra | 1936–1946 | 63 | 2 | 214 | |
| Jeff Suppan | 1995–2012 | 76 | 1 | 1,390 | |
| B.J. Surhoff | 1987–2005 | 2,326 | 188 | 0 | 3 |
| Max Surkont | 1949–1957 | 63 | 1 | 575 | |
| George Susce | 1955–1959 | 17 | 0 | 177 | 1 |
| Rick Sutcliffe | 1976–1994 | 102 | 4 | 1,679 | |
| Brent Suter | 2016–2026 | 8 | 1 | 559 | |
| Gary Sutherland | 1966–1978 | 754 | 24 | 0 | |
| Bruce Sutter | 1976–1988 | 9 | 0 | 861 | |
| Jack Sutthoff | 1898–1905 | 35 | 0 | 202 | |
| Mule Suttles | 1928–1948 | 418 | 100 | 4 | 1 |
| Don Sutton | 1966–1988 | 195 | 0 | 3,574 | 6 |
| Jack Suwinski | 2022–2025 | 233 | 57 | 0 | 1 |
| Ichiro Suzuki | 2001–2019 | 3,089 | 117 | 0 | |
| Kurt Suzuki | 2007–2022 | 1,421 | 143 | 0 | 1 |
| Mac Suzuki | 1996–2002 | 2 | 0 | 327 | |
| Seiya Suzuki | 2022–2026 | 661 | 110 | 0 | 1 |
| Dale Sveum | 1986–1999 | 597 | 69 | 0 | 1 |
| Harry Swacina | 1907–1915 | 304 | 1 | 0 | 1 |
| Craig Swan | 1973–1984 | 54 | 1 | 673 | |
| Dansby Swanson | 2016–2026 | 1,273 | 182 | 0 | 3 |
| Evar Swanson | 1929–1934 | 572 | 7 | 0 | 1 |
| Anthony Swarzak | 2009–2021 | 0 | 0 | 494 | |
| Bill Sweeney | 1907–1914 | 1,004 | 11 | 0 | 4 |
| Bill Sweeney | 1928–1931 | 299 | 5 | 0 | 1 |
| Jeff Sweeney | 1908–1919 | 426 | 3 | 0 | 4 |
| Mark Sweeney | 1995–2008 | 464 | 42 | 0 | 1 |
| Mike Sweeney | 1995–2010 | 1,540 | 215 | 0 | 1 |
| Ryan Sweeney | 2006–2014 | 584 | 23 | 0 | 1 |
| Les Sweetland | 1927–1931 | 78 | 0 | 156 | |
| Steve Swetonic | 1929–1935 | 34 | 0 | 153 | |
| Bill Swift | 1932–1943 | 134 | 3 | 638 | |
| Bill Swift | 1985–1998 | 48 | 1 | 767 | |
| Bob Swift | 1940–1953 | 635 | 14 | 0 | 2 |
| Greg Swindell | 1986–2002 | 46 | 0 | 1,542 | |
| Nick Swisher | 2004–2015 | 1,338 | 245 | 1 | 1 |
| Steve Swisher | 1974–1982 | 305 | 20 | 0 | |
| Ron Swoboda | 1965–1973 | 624 | 73 | 0 | 4 |
| Bob Sykes | 1977–1981 | 6 | 0 | 215 | |
| Noah Syndergaard | 2015–2023 | 34 | 6 | 928 | |
| Matt Szczur | 2014–2018 | 136 | 12 | 0 | 1 |