A team has finished a game with 22 left on base 42 times since 1897, most recently New York Mets on 8 June 2013. That is about one every 10,547 team-games.
Box score for the most recent one ↗
16 17 18 19 20 21 22 23 24 25 26 27
The whole distribution — Runners Left on Base · All 18 shapes