There have been 19 four-homer games since 1932, measured across 227,342 games — one every 11,965 games. The most recent was Kyle Schwarber on 28 August 2025; the first was Lou Gehrig on 3 June 1932.
| Date | Player | # | Game | |
|---|---|---|---|---|
| 2025-08-28 | Kyle Schwarber | 4 | 19 | ↗ |
| 2025-07-25 | Nick Kurtz | 4 | 18 | ↗ |
| 2025-04-26 | Eugenio Suarez | 4 | 17 | ↗ |
| 2017-09-04 | J.D. Martinez | 4 | 16 | ↗ |
| 2017-06-06 | Scooter Gennett | 4 | 15 | ↗ |
| 2012-05-08 | Josh Hamilton | 4 | 14 | ↗ |
| 2003-09-25 | Carlos Delgado | 4 | 13 | ↗ |
| 2002-05-23 | Shawn Green | 4 | 12 | ↗ |
| 2002-05-02 | Mike Cameron | 4 | 11 | ↗ |
| 1993-09-07 | Mark Whiten | 4 | 10 | ↗ |
| 1986-07-06 | Bob Horner | 4 | 9 | ↗ |
| 1976-04-17 | Mike Schmidt | 4 | 8 | ↗ |
| 1961-04-30 | Willie Mays | 4 | 7 | ↗ |
| 1959-06-10 | Rocky Colavito | 4 | 6 | ↗ |
| 1954-07-31 | Joe Adcock | 4 | 5 | ↗ |
| 1950-08-31 | Gil Hodges | 4 | 4 | ↗ |
| 1948-07-18 | Pat Seerey | 4 | 3 | ↗ |
| 1936-07-10 | Chuck Klein | 4 | 2 | ↗ |
| 1932-06-03 | Lou Gehrig | 4 | 1 | ↗ |