49-21 in NFL history
5 completed games with this score pair in the covered 7,355 games. Scores list the higher score first, regardless of home or away.
| Date | Matchup | Result |
|---|---|---|
| 2016-11-27 | LA at NO | 21–49 |
| 2012-01-01 | BUF at NE | 21–49 |
| 2005-10-30 | PHI at DEN | 21–49 |
| 2004-11-15 | PHI at DAL | 49–21 |
| 2002-09-08 | DET at MIA | 21–49 |
Sources and coverage
Derived from nflverse data. Player and schedule histories start in 1999; drive and play findings currently cover the 2026 season. Updated 2026-10-15. Recent results can change after official scoring corrections. Source terms and attribution.